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Here we describe our comprehensive structure-activity relationship (SAR) studies of this chemicalseries.
2
Identification, synthesis and structure-activity relationship of small-molecule VIPR1 antagonists encompassing two chemicalseries are described.
3
Although several chemicalseries of PHD inhibitors have been described, significant isoform selectivity has not been reported.
4
We describe two chemicalseries that bind to the myristoyl site of the c-Abl kinase domain and stimulate c-Abl activation.
5
Here, we further investigate the mechanisms of action of the most active of this chemicalseries, isopimpinellin, in our zebrafish model of neutrophilic inflammation.